악관절환자에서 Synovial fluid에 대한 단백질체 분석에 관한 연구
The analysis of synovial fluid by proteomics from TMD
변은선, 김태우, 김상균, 박태일, 박준우, 윤필영, 김영균, 채창훈,
소속 상세정보
변은선 ( Byun Eun-Sun ) - 서울대학교 치과대학 교정학교실
김태우 ( Kim Tae-Woo ) - 서울대학교 치과대학 치과교정학교실
김상균 ( Kim Sang-Hyun ) - 한림대학교 의과대학 구강악안면외과학교실
박태일 ( Park Tae-Il ) - 한림대학교 의과대학 구강악안면외과학교실
박준우 ( Park Jun-Woo ) - 한림대학교 의과대학 구강악안면외과학교실
윤필영 ( Yun Pil-Young ) - 분당서울대학교병원 치과 구강악안면외과
김영균 ( Kim Young-Kyun ) - 분당서울대학교병원 구강악안면외과
채창훈 ( Chae Chang-Hoon ) - 나노큐어텍 나노-바이오 퓨전 부설연구소
KMID : 0355620080340020113
Abstract
Temporomandibular joint disorder (TMD) can induce severe pain but, its pathogenic mechanisms remain poorly understood. In this study, we analyzed proteomes of human synovial fluid in the superior joint space in the patients with TMD, which is obtained during the treatment arthrocentesis. We’ve got this result that one of the spots was consistently down-regulated in synovial fluid of patients with TMD from analysis of protein pattern. Its molecular weight was estimated to be 33 kDa. Synoviolin was identified in our proteomics analysis of LC/MS/MS. This protein was recently reported as one of the proteins that might affect rheumatoid arthritis (RA). Synoviolin that might be associated with RA was detected in synovial fluid of patients with TMD. We can conclude that synoviolin might be involved not only in the pathogenesis of RA but also in TMD. In result, synoviolin might be involved in the pathogenesis of TMD and can be candidates as new therapeutic targets of TMD or early detection biomarkers.
키워드
Temporomandibular joint disorder (TMD);Proteomics;Synoviolin
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